As an English major/childhood pro wrestling fan, this story of the fabulous true friendship between Samuel Beckett and Andre the Giant delighted me to no end. Surely some type of play/film/sitcom/mystery show where they drive around in the truck solving crimes needs to be made from this scenario. I guess you could reference cricket just a bit...perhaps have Andre's catchphrase be "This is a sticky wicket," or have Andre and Sam be accompanied on their adventures by a talking cartoon cricket named Sir Donald.
I think you could have Paul Rudd as Beckett if you added enough old age makeup, since clearly, Jason Segel is the only choice to play Andre. Is "Waiting For Andre" too obvious a title?